2-Phenylpyridine → 2-(2-Bromophenyl)pyridine

Temperatur

0 °C

3 g (19.3 mmol) of 2-phenyl pyridine and 40 mg (0.716 mmol) of iron powder were mixed and stirred. It was cooled to 0° C. and 4.0 g (25 mmol) of bromine was added dropwise with stirring, and watching heat generation, and it was raised to 90° C., and stirred for 10 hours. After the reaction, this reaction mixture was dissolved in chloroform to produce a solution, which was washed with 5% sodium thiosulfate aqueous solution. The chloroform solution was dried with sodium sulfate, and then concentrated. The residue was purified by silica gel column chromatography, and the desired 2-(bromophenyl)pyridine was obtained.

1. stirringwith stirring
2. temperaturewatching heat generation, and it
3. temperaturewas raised to 90° C.
4. stirringstirred for 10 hours
5. customAfter the reaction
6. customto produce a solution, which
7. washwas washed with 5% sodium thiosulfate aqueous solution
8. dry with materialThe chloroform solution was dried with sodium sulfate
9. concentrationconcentrated
10. customThe residue was purified by silica gel column chromatography

ORD-Eintrag

ord-8958d83f4bb5430fae065f23e858a49b

Quelldatensatz

uspto-grants-2011_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08003226B2