Triphenylphosphine → 5-Chloro-2-methoxybenzene-1-thiol

HRID 1675590Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1675590
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([O:31][CH3:32])=[C:25]([S:27](Cl)(=O)=O)[CH:26]=1>C1COCC1.O>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([O:31][CH3:32])=[C:25]([SH:27])[CH:26]=1

Komponenten

5

Edukt 2

HCID 11776TriphenylphosphineHCID 27342725-Chloro-2-methoxybenzene-1-sulfonyl chloride

Produkt 1

HCID 127727855-Chloro-2-methoxybenzene-1-thiol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittel2×HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Triphenylphosphine (11.4 g) was added portionwise to a stirred solution of 5-chloro-2-methoxybenzenesulphonyl chloride (3.0 g) in THF (30 ml). Water (4 ml) was added and the mixture stirred at RT for 2 h, after which the reaction was diluted with water (25 ml) then 2M sodium hydroxide solution and washed with ether. The aqueous layer was acidified with 2M hydrochloric acid and extracted with ethylacetate. The organic layer was dried and evaporated under reduced pressure, yield 3.1 g.

Aufarbeitung

  1. wash2M sodium hydroxide solution and washed with ether
  2. extractionextracted with ethylacetate
  3. customThe organic layer was dried
  4. customevaporated under reduced pressure, yield 3.1 g

Quellen und Nachweise

ORD-Eintrag
ord-c802e92cd8f549e28bc7519933a6f9ba
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08003703B2

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