1,2-Dichloroethane → HCID 67374131, Verbindung

HRID 1677609

Reaktionsgleichung

Reaktionsgleichung von HRID 1677609
[CH2:1]([O:8][C:9]([NH:11][CH:12]([P:16]([OH:18])[OH:17])[CH:13]([CH3:15])[CH3:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:19](Cl)[CH2:20]Cl>C(O)C.C(Cl)Cl>[CH2:19]([O:18][P:16]([CH:12]([NH:11][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:10])[CH:13]([CH3:15])[CH3:14])[OH:17])[CH3:20]

Komponenten

5

Edukt 2

HCID 111,2-DichloroethaneHCID 213258521-Carbobenzyloxyamino-2-methylpropanephosphonous acid

Produkt 1

HCID 67374131HCID 67374131, VerbindungAusbeute 96,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 1-(benzyloxycarbonylamino)-2-methylpropylphosphonous acid (5.8 g, 21.4 mmol) in 15 mL ethanol and 200 mL CH2Cl2 was added EDC (5.0 g, 26 mmol). The resulting reaction mixture was stirred at ambient temperature for 30 minutes. The mixture was concentrated in vacuo, and the residue was taken up into 200 mL ethyl acetate, washed with water and brine. The solvent was evaporated in vacuo to afford 1-(benzyloxycarbonylamino)-2-methylpropylphosphonous acid ethyl ester (6.2 g, 20.7 mmol, 96.8%) as white solid which was used without further purification.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. concentrationThe mixture was concentrated in vacuo
  3. washwashed with water and brine
  4. customThe solvent was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5cdb2f8cf7d84ef9827e13655a9d5e5f
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008325B2

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