Water → 4-(Bromomethyl)-N-methylbenzenesulfonamide

HRID 1677679Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1677679
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.Cl.[CH3:14][NH2:15].O>C(Cl)Cl>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:15][CH3:14])(=[O:11])=[O:10])=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 27344094-(Bromomethyl)benzenesulfonyl chlorideHCID 6364545Methylamine hydrochloride

Produkt 1

HCID 100156454-(Bromomethyl)-N-methylbenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a chilled (0° C.) stirred solution of 4-(bromomethyl)-benzenesulfonylchloride (3.0 g, 11 mmol) in DCM (100 mL) was added methylamine hydrochloride (1.2 g, 12 mmol). After 30 minutes, water (100 mL) was added. The organic layer was separated, washed with brine (30 mL), and dried over sodium sulfate and concentrated in vacuo to afford 4-bromomethyl-N-methyl-benzenesulfonamide.

Aufarbeitung

  1. customThe organic layer was separated
  2. washwashed with brine (30 mL)
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cb5e702125644c1baa2830aef7bc2f58
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008327B2

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