Dimethylformamide → 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid chloride

HRID 1677684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1677684
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[CH:15]=[CH:14][CH:13]=[C:12]([C:17]([OH:19])=O)[C:11]=3[CH:10]=[N:9]2)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:23])=O.CN(C=O)C>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[CH:15]=[CH:14][CH:13]=[C:12]([C:17]([Cl:23])=[O:19])[C:11]=3[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 581387741-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid

Produkt 1

HCID 581388741-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (0.400 g, 1.56 mmol) in CH2Cl2 (5 mL) at room temperature was added oxalyl chloride (0.86 mL, 1.7 mmol) followed by DMF (20 μL). Gas evolution was observed. After 30 minutes, the solution was concentrated in vacuo to afford 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid chloride which was used without further purification.

Aufarbeitung

  1. concentrationthe solution was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e41f226dbe4e4507ab63d5255e655d25
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008327B2

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