Hydrochloric Acid → 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperazine dihydrochloride

HRID 1677739Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1677739
[C:1]1([C:7]2[O:11][N:10]=[C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:25]>CCOCC>[ClH:25].[ClH:25].[C:1]1([C:7]2[O:11][N:10]=[C:9]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 11992900Tert-butyl 4-(5-phenyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate

Produkt 1

HCID 673331091-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperazine dihydrochlorideAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of tert-butyl 4-(5-phenyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate (5 g) in a 2M solution of HCl in ether (100 mL) was stirred at RT for 6 hours. The solvent was removed under vacuum to afford 4.3 g (93%) of the title compound as a solid. TLC—Chloroform/methanol (8/2): Rf=0.2. HPLC purity: 97%.

Aufarbeitung

  1. customThe solvent was removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-cdc7ecaeeaae4a48bcad63d5e6449236
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008302B2

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