Triethylamine → [2-Methyl-3'-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-yl]-carbamic acid tert-butyl ester

HRID 1678458Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1678458
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21](O)=[O:22])[CH:16]=2)=[C:11]([CH3:24])[CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N:25]1([C:31]2[CH:37]=[CH:36][C:34]([NH2:35])=[CH:33][CH:32]=2)[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1.C(N(CC)CC)C.F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2C=CC=CC=2N=N1>CN(C=O)C.O>[C:1]([O:5][C:6](=[O:7])[NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21](=[O:22])[NH:35][C:34]3[CH:36]=[CH:37][C:31]([N:25]4[CH2:26][CH2:27][O:28][CH2:29][CH2:30]4)=[CH:32][CH:33]=3)[CH:16]=2)=[C:11]([CH3:24])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

7

Edukt 4

HCID 8471TriethylamineHCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 598223634'-tert-Butoxycarbonylamino-2'-methyl-biphenyl-3-carboxylic acid

Produkt 1

HCID 59822359[2-Methyl-3'-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-yl]-carbamic acid tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 4′-tert-butoxycarbonylamino-2′-methyl-biphenyl-3-carboxylic acid (436 mg), 4-morpholin-4-yl aniline (238 mg), triethylamine (0.55 ml) and O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate (757 mg) in dry DMF (1 ml) was stirred at 20 C for 18 h. Water (50 ml) was then added and the resulting colourless precipitate was collected by filtration and dried (680 mg)

Aufarbeitung

  1. filtrationthe resulting colourless precipitate was collected by filtration
  2. customdried (680 mg)

Quellen und Nachweise

ORD-Eintrag
ord-b2ec8780220443e68cdffdbc65bcc0e2
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008303B2

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