Methanethiol → 2-Chloro-6-(methylsulfanyl)pyrazine

HRID 1679661Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1679661
[Na].[H-].[Na+].[CH3:4][SH:5].[Cl:6][C:7]1[CH:12]=[N:11][CH:10]=[C:9](Cl)[N:8]=1>C1C=CC=CC=1>[Cl:6][C:7]1[CH:12]=[N:11][CH:10]=[C:9]([S:5][CH3:4])[N:8]=1

Komponenten

6

Edukt 4

HCID 878MethanethiolHCID 24758Sodium hydrideHCID 785042,6-DichloropyrazineHCID 5360545Sodium

Produkt 1

HCID 203616852-Chloro-6-(methylsulfanyl)pyrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

A mixture of 0.13 mole of sodium methylmercaptide (prepared from 3.12 g. sodium hydride and excess methyl mercaptan), 20 g. (0.13 mole) of 2,6-dichloropyrazine and 200 ml. benzene is heated at reflux for 24 hours, cooled and washed twice with 50 ml. water. The benzene layer is separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Distillation of the residue gives 2-chloro-6-methylthiopyrazine.

Aufarbeitung

  1. temperatureat reflux for 24 hours
  2. temperaturecooled
  3. washwashed twice with 50 ml
  4. customThe benzene layer is separated
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. distillationDistillation of the residue

Quellen und Nachweise

ORD-Eintrag
ord-51ce95e9ccca438d8bee797a9daa1d48
Quelldatensatz
uspto-grants-1978_03
Patentnummer
US04081542

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