Ammonium Hydroxide → HCID 70575784, Verbindung

HRID 1680483Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1680483
[OH-].[NH4+:2].C([O:5][C:6]([CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([CH2:18][C:19]2[NH:20][CH:21]=[CH:22][N:23]=2)=[CH:10]1)=O)C>C(O)C>[C:6]([CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([CH2:18][C:19]2[NH:20][CH:21]=[CH:22][N:23]=2)=[CH:10]1)(=[O:5])[NH2:2]

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 70574941HCID 70574941, Verbindung

Produkt 1

HCID 70575784HCID 70575784, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Concentrated ammonium hydroxide (10 ml, S.G. 0.880) was added to a solution of 1-ethoxycarbonylmethyl-3-(1-imidazolylmethyl) indole (0.50 g) in ethanol (5 ml) and the mixture was stirred at room temperature for 2 hours. The solid was filtered off, washed with water, dried and crystallised from ethanol/petrol (b.p. 60°-80° C.) to give 1-carbamoylmethyl-3-(1-imidazolylmethyl)indole (0.24 g), m.p. 211°-212° C. Found: C, 65.65; H, 5.58; N, 21.69. C14H14N4O requires: C, 66.12; H, 5.55; N, 22.04.

Aufarbeitung

  1. filtrationThe solid was filtered off
  2. washwashed with water
  3. customdried
  4. customcrystallised from ethanol/petrol (b.p. 60°-80° C.)

Quellen und Nachweise

ORD-Eintrag
ord-7d19326184934b2bb8e6d07f06c7d6a3
Quelldatensatz
uspto-grants-1981_06
Patentnummer
US04273782

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