Imidazole → Acetophenone, 2-(1-imidazolyl)-2',3',5',6'-tetramethyl-

HRID 1680650Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1680650
Br[CH2:2][C:3]([C:5]1[C:11]([CH3:12])=[C:10]([CH3:13])[CH:9]=[C:7]([CH3:8])[C:6]=1[CH3:14])=[O:4].CN(C)C=O.[NH:20]1[CH:24]=[CH:23][N:22]=[CH:21]1>O>[N:20]1([CH2:2][C:3]([C:5]2[C:11]([CH3:12])=[C:10]([CH3:13])[CH:9]=[C:7]([CH3:8])[C:6]=2[CH3:14])=[O:4])[CH:24]=[CH:23][N:22]=[CH:21]1

Komponenten

5

Edukt 3

HCID 795ImidazoleHCID 6228DimethylformamideHCID 2648242-bromo-1-(2,3,5,6-tetramethylphenyl)ethanone

Produkt 1

HCID 52759Acetophenone, 2-(1-imidazolyl)-2',3',5',6'-tetramethyl-Ausbeute 62 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture containing 2.55 g of 3-bromoacetyl-durene, prepared as described in Example 4, 3 ml of dimethylformamide and 3.40 g of imidazole, was stirred for 8 hours at 80° C. At the end of the reaction, the mixture was cooled to room temperature and 25 ml of water were added. The precipitate thus obtained was filtered off, dried and crystallized from benzene to give 1.5 g of the title compound. M.P. 176°-8° C., yield 62%.

Aufarbeitung

  1. customprepared
  2. customAt the end of the reaction
  3. temperaturethe mixture was cooled to room temperature
  4. customThe precipitate thus obtained
  5. filtrationwas filtered off
  6. customdried
  7. customcrystallized from benzene

Quellen und Nachweise

ORD-Eintrag
ord-432d2bfa73a04984a77de39e461e182b
Quelldatensatz
uspto-grants-1981_06
Patentnummer
US04275071

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