Hydrochloric Acid → 4,5,6,7-Tetrafluorobenzothiophen-2-carboxylic acid

HRID 1681297

Reaktionsgleichung

Reaktionsgleichung von HRID 1681297
F[C:2]1[C:15]([F:16])=[C:14]([F:17])[C:13]([F:18])=[C:12]([F:19])[C:3]=1[CH:4]=[C:5]1[S:9]C(=S)N[C:6]1=[O:11].[OH-:20].[Na+].Cl>O>[F:19][C:12]1[C:3]2[CH:4]=[C:5]([C:6]([OH:20])=[O:11])[S:9][C:2]=2[C:15]([F:16])=[C:14]([F:17])[C:13]=1[F:18]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 49072912,3,4,5,6-Pentafluorobenzylidene rhodanine

Produkt 1

HCID 109886834,5,6,7-Tetrafluorobenzothiophen-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

78 g of 2,3,4,5,6-pentafluorobenzylidene rhodanine were added in small portions to a stirred solution of 68 g of NaOH in 300 ml of water. The resultant clear red solution was heated to 90° C. for one hour, cooled in ice, acidified with concentrated HCl, and the cream coloured solid which was produced was filtered and washed. The crude product (59 g) was purified by sublimation to give 4,5,6,7-tetrafluorobenzothiophen-2-carboxylic acid having a melting point of 200° C.

Aufarbeitung

  1. temperaturecooled in ice
  2. customwas produced
  3. filtrationwas filtered
  4. washwashed
  5. customThe crude product (59 g) was purified by sublimation

Quellen und Nachweise

ORD-Eintrag
ord-037c9a762c0c4634b5d80f423aff29cb
Quelldatensatz
uspto-grants-1992_12
Patentnummer
US05169983

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