HCID 21612897, Verbindung → HCID 19804938, Verbindung

HRID 1682327Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1682327
C([O:3][C:4](=[O:22])[CH:5]([NH:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)/[CH:6]=[C:7](\[CH3:13])/[CH2:8][P:9]([OH:12])([OH:11])=[O:10])C>O>[CH2:15]([NH:14][CH:5](/[CH:6]=[C:7](\[CH3:13])/[CH2:8][P:9]([OH:11])([OH:12])=[O:10])[C:4]([OH:22])=[O:3])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Komponenten

3

Edukt 1

HCID 21612897HCID 21612897, Verbindung

Produkt 1

HCID 19804938HCID 19804938, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 1.00 g of E-2-benzylamino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester in 6 ml of water is stirred under reflux for 20 hours. The reaction mixture is concentrated to dryness by evaporation in vacuo. Ethanol is added to the residue, and the mixture is again concentrated by evaporation. This process is repeated twice more. The residue is dissolved in boiling methanol. After cooling there is obtained crystalline E-2-benzylamino-4-methyl-5-phosphono-3-pentenoic acid, m.p. 150° (decomp.).

Aufarbeitung

  1. temperatureunder reflux for 20 hours
  2. concentrationThe reaction mixture is concentrated to dryness by evaporation in vacuo
  3. additionEthanol is added to the residue
  4. concentrationthe mixture is again concentrated by evaporation
  5. dissolutionThe residue is dissolved
  6. temperatureAfter cooling there

Quellen und Nachweise

ORD-Eintrag
ord-5957bc2bcd3d4e96bac6fb48987e8bad
Quelldatensatz
uspto-grants-1992_12
Patentnummer
US05175344

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