Sodium Methoxide → N-benzoyl-3-methoxycaprolactam

HRID 1682379Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1682379
ClC1CCCNC(=O)C1.C[O-].[Na+].[C:13]([N:21]1[CH2:26][CH2:25]O[CH2:23][C:22]1=[O:27])(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH3:28][O:29][CH:30]1[CH2:37][CH2:36][CH2:35][NH:34][C:32](=[O:33])[CH2:31]1>>[CH3:28][O:29][CH:30]1[CH2:37][CH2:36][CH2:35][NH:34][C:32](=[O:33])[CH2:31]1.[C:13]([N:21]1[CH2:26][CH2:25][CH2:31][CH:30]([O:29][CH3:28])[CH2:23][C:22]1=[O:27])(=[O:20])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Komponenten

6

Edukt 4

HCID 10942334Sodium MethoxideHCID 122940964-Benzoylmorpholin-3-oneHCID 190438224-Methoxyazepan-2-oneHCID 193693183-Chlorocaprolactam

Produkt 2

HCID 19043821N-benzoyl-3-methoxycaprolactamHCID 190438224-Methoxyazepan-2-one

Versuchsvorschrift

3-Methoxycaprolactam was prepared from 3-chlorocaprolactam (prepared as described in Francis, et al. J. Am. Chem. Soc. 1958, 80, 6238) and sodium methoxide according to the method of Kondelikova, et al. (Collect. Czech. Chem. Commun. 1971, 36(9), 3391). The desired product N-benzoyl-3-methoxycaprolactam is synthesized as for N-benzoyl-3-oxomorpholine (Example I) using 3 -methoxycaprolactam in place of morpholin-3-one.

Quellen und Nachweise

ORD-Eintrag
ord-9aa69dbbb2814954beb15485a083d590
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05635103

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