Water → Pyridine-2-carbothioamide

HRID 1682425

Reaktionsgleichung

Reaktionsgleichung von HRID 1682425
P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:2].[NH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)=O.O>O1CCCC1>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:16](=[S:2])[NH2:15]

Komponenten

5

Edukt 3

HCID 962WaterHCID 14817Phosphorus sulfide (P2S5)HCID 150702-Pyridinecarboxamide

Produkt 1

HCID 1549499Pyridine-2-carbothioamideAusbeute 74,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

43 g of phosphorus pentasulfide were added slowly to 46.8 g of the amide of Stage A in 700 ml of tetrahydrofuran and the mixture was stirred for 4 hours at ambient temperature. The reaction mixture was poured into water and extracted with ether. The extracts were dried and the solvent was evaporated under reduced pressure. After chromatography on silica (eluant: CH2Cl2 --AcOEt 8-2), 10 g of expected product melting at 137° C. were obtained.

Aufarbeitung

  1. extractionextracted with ether
  2. customThe extracts were dried
  3. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-189d08015cd14c07b7bc2532edc628c1
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05635485

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