Benzene → 2-{2-[3,4-Bis(methoxycarbonyl)phenoxy]-1-methylethyl}amino-1-(3-chlorophenyl)ethanol

HRID 1682745

Reaktionsgleichung

Reaktionsgleichung von HRID 1682745
[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=1)[OH:4].O=[C:13]([CH3:30])[CH2:14][O:15][C:16]1[CH:17]=[C:18]([C:26]([O:28][CH3:29])=[O:27])[C:19](=[CH:24][CH:25]=1)[C:20]([O:22][CH3:23])=[O:21].C1C=CC=CC=1.[BH4-].[Na+]>CO>[CH3:29][O:28][C:26]([C:18]1[CH:17]=[C:16]([CH:25]=[CH:24][C:19]=1[C:20]([O:22][CH3:23])=[O:21])[O:15][CH2:14][CH:13]([NH:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=1)[OH:4])[CH3:30])=[O:27]

Komponenten

6

Edukt 4

HCID 241BenzeneHCID 37516012-Amino-1-(3-chlorophenyl)ethan-1-olHCID 4311764Sodium borohydrideHCID 21832192Dimethyl 4-(2-oxopropoxy)phthalate

Produkt 1

HCID 218321612-{2-[3,4-Bis(methoxycarbonyl)phenoxy]-1-methylethyl}amino-1-(3-chlorophenyl)ethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Following a procedure similar to that described in Example 6, but using 2 g of 2-amino-1-(3-chlorophenyl)ethanol (prepared as described in Preparation 8), 3.73 g of dimethyl 4-(2-oxopropoxy)phthalate (prepared as described in Preparation 54), 70 ml of benzene, 60 ml of absolute methanol and 1.32 g of sodium borohydride, the title compound was obtained having an Rf=0.29 (thin layer chromatography over silica gel, using ethyl acetate as the developing solvent).

Quellen und Nachweise

ORD-Eintrag
ord-679ba6a447514a6a9c694dd824d99c8a
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05635534

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