Oxalyl chloride → 3-Isopropoxy-phenyl-acetyl chloride

HRID 1683031Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1683031
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([OH:14])=O)[CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2].C(Cl)(=O)C([Cl:18])=O>CN(C)C=O.ClCCl>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([Cl:18])=[O:14])[CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 166389242-(3-(Propan-2-yloxy)phenyl)acetic acid

Produkt 1

HCID 183334403-Isopropoxy-phenyl-acetyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
-5 °C

Versuchsvorschrift

Combine 3-isopropoxy-phenyl-acetic acid (0.5 g, 2.6 mmol) and dichloromethane (5 mL). Cool to -5° C. using a ice-salt bath. Add 2 drops of dimethylformamide followed by dropwise addition of oxalyl chloride (0.34 g, 2.7 mmol). after 1 hour, warm the reaction mixture to ambient temperature. After 2 hours, evaporate the reaction mixture in vacuo to give the title compound as a liquid.

Aufarbeitung

  1. temperaturewarm the reaction mixture to ambient temperature
  2. waitAfter 2 hours
  3. customevaporate the reaction mixture in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-724d2564be8a4b2da2fa28840bcab7b8
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05635510

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