Bromine → 2-(2-imino-3-(2-(piperidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(thiophen-2-yl)ethanone hydrobromide

HRID 1683725

Reaktionsgleichung

Reaktionsgleichung von HRID 1683725
[Br:1][CH2:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)=[O:4].BrBr.[NH2:12][C:13]1[N:17]([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:16]2[CH:26]=[CH:27][CH:28]=[CH:29][C:15]=2[N:14]=1>CC(C)=O>[Br-:1].[NH2:12][C:13]1[N:14]([CH2:2][C:3](=[O:4])[C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)[C:15]2[CH:29]=[CH:28][CH:27]=[CH:26][C:16]=2[N+:17]=1[CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Komponenten

5

Edukt 3

HCID 24408BromineHCID 5665591-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-amineHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

Produkt 1

HCID 1785085292-(2-imino-3-(2-(piperidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(thiophen-2-yl)ethanone hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

An ethereal solution of 2-bromoacetylthiophene (obtained by brominating 2-acetylthiophene (1.9 g, 15 mmol) with 0.8 ml (15 mmol) of bromine in 10 ml of dioxane and 15 ml of ether) is added to a hot solution of 2-amino-1-(2-piperidinoethyl)benzimidazole (2.44 g; 10 mmol) in 100 ml of acetone. Stir and maintain at room temperature. The next day, the title compound precipitate is collected by means of filtration and washed with acetone and with ether.

Aufarbeitung

  1. filtrationThe next day, the title compound precipitate is collected by means of filtration
  2. washwashed with acetone and with ether

Quellen und Nachweise

ORD-Eintrag
ord-32aaa76fc6324ca396b97f4b3f22d62d
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05639756

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