Hydrochloric Acid → 1-(4-chlorophenyl)-2-(3,4-dihydropyrimido[1,2-a]benzimidazol-10(2H)-yl)ethanol

HRID 1683729Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1683729
[BH4-].[Na+].[Cl:3][C:4]1[CH:25]=[CH:24][C:7]([C:8](=[O:23])[CH2:9][N:10]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[N:12]3[CH2:19][CH2:20][CH2:21][N:22]=[C:11]23)=[CH:6][CH:5]=1.Cl>C(O)C>[OH:23][CH:8]([C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:25][CH:24]=1)[CH2:9][N:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]2[CH2:19][CH2:20][CH2:21][N:22]=[C:11]12

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 791782HCID 791782, VerbindungHCID 4311764Sodium borohydride

Produkt 1

HCID 28997651-(4-chlorophenyl)-2-(3,4-dihydropyrimido[1,2-a]benzimidazol-10(2H)-yl)ethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Add 0.35 g (9.3 mmol) of sodium borohydride in small portions, with vigorous stirring, to a suspension of 3.0 g (9.3 mmol) of 10-(4-chlorophenacyl)-2,3,4,10-tetrahydropyrimidino[1,2-a]benzimidazole (obtained in Example 50) in 20 ml of ethanol. Maintain stirring for one hour and leave for 12 hours at room temperature. Acidify with hydrochloric acid, and evaporate the reaction mixture. Treat the residue with ammonium hydroxide and extract with chloroform. The organic phase obtained is passed over a column of alumina. Evaporate the solvent. The residue is the title compound.

Aufarbeitung

  1. temperatureMaintain
  2. customleave for 12 hours at room temperature
  3. customevaporate the reaction mixture
  4. additionTreat the residue with ammonium hydroxide
  5. extractionextract with chloroform
  6. customThe organic phase obtained
  7. customEvaporate the solvent

Quellen und Nachweise

ORD-Eintrag
ord-1cbd5d10e6604fc8bd394ae2639bf8b0
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05639756

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