Hydrazine hydrate (1:1) → 5-(4-Chloro-phenyl)-2,4-dihydro-pyrazol-3-one

HRID 1683804Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1683804
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]([C:8](C)(C)[C:9](OCC)=[O:10])=O)=[CH:4][CH:3]=1.O.[NH2:19][NH2:20]>C(O)C>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]2[CH2:8][C:9](=[O:10])[NH:20][N:19]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 16638375HCID 16638375, Verbindung

Produkt 1

HCID 47787935-(4-Chloro-phenyl)-2,4-dihydro-pyrazol-3-oneAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 26 g (0.10 mol) of ethyl α-(4-chlorobenzoyl)isobutyrate, 10 g (0.20 mol) of hydrazine monohydrate and 200 ml of ethanol was heated under reflux for 18 hours. The reaction solution was concentrated under reduced pressure. The obtained crude product was washed successively with water, methanol-water and diethyl ether-n-hexane and then air dried, to give 16 g of the object compound as white crystals (yield 84%).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. customThe obtained crude product
  5. washwas washed successively with water, methanol-water and diethyl ether-n-hexane
  6. customair dried

Quellen und Nachweise

ORD-Eintrag
ord-4f1fa64591d9473e9881a76344a700ce
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05639776

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