Hydrazine hydrate (1:1) → 5-(4-Chloro-phenyl)-2,4-dihydro-pyrazol-3-one

HRID 1683810Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1683810
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]([C:8](C)(C)[C:9](OCC)=[O:10])=O)=[CH:4][CH:3]=1.O.[NH2:19][NH2:20]>C(O)C>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]2[CH2:8][C:9](=[O:10])[NH:20][N:19]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 16638375HCID 16638375, Verbindung

Produkt 1

HCID 47787935-(4-Chloro-phenyl)-2,4-dihydro-pyrazol-3-oneAusbeute 82.212,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 26 g (0.10 mmol) of ethyl α-(4-chlorobenzoyl)isobutyrate, 10 g (0.20 mmol) of hydrazine monohydrate and 200 ml of ethanol was heated under reflux for 18 hours. The reaction solution was concentrated under reduced pressure. The obtained crude product was washed successively with water, methanol-water and diethyl ether-n-hexane, and then air dried to give 16 g of the object compound as white crystals (yield 84%).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. customThe obtained crude product
  5. washwas washed successively with water, methanol-water and diethyl ether-n-hexane
  6. customair dried

Quellen und Nachweise

ORD-Eintrag
ord-5449332995294ab599caac6f51e011c8
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05639776

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