2,3-dihydro-6-methoxy-1H-isoindol-5-ol → alpha-(3,4-Dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-alpha-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile

HRID 1684392

Reaktionsgleichung

Reaktionsgleichung von HRID 1684392
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][NH:8][CH2:9]2)=[CH:5][C:4]=1[OH:12].Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([S:32][C:33]1[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][CH:34]=1)([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([O:30][CH3:31])[CH:23]=1)[C:20]#[N:21]>>[CH3:31][O:30][C:24]1[CH:23]=[C:22]([C:19]([S:32][C:33]2[CH:34]=[CH:35][C:36]([CH3:39])=[CH:37][CH:38]=2)([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][N:8]2[CH2:7][C:6]3[C:10](=[CH:11][C:3]([O:2][CH3:1])=[C:4]([OH:12])[CH:5]=3)[CH2:9]2)[C:20]#[N:21])[CH:27]=[CH:26][C:25]=1[O:28][CH3:29]

Komponenten

3

Edukt 2

HCID 102411352,3-dihydro-6-methoxy-1H-isoindol-5-olHCID 10527448alpha-(5-Bromopentyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)thio]benzeneacetonitrile

Produkt 1

HCID 10530307alpha-(3,4-Dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-alpha-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrileAusbeute 74,2 %

Versuchsvorschrift

The procedure of Example 49 is used with 0.209 g of 2,3-dihydro-6-methoxy-1H-isoindol-5-ol (Example 105) and 0.57 g of α-(5-bromopentyl)-3,4- dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile. This affords 0.5 g of the desired product as a gray foam.

Quellen und Nachweise

ORD-Eintrag
ord-302529887b174f77aecaf6a1af026878
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05639887

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