Sodium borohydride → 3-Bromo-2-fluorobenzyl Alcohol

HRID 1684918

Reaktionsgleichung

Reaktionsgleichung von HRID 1684918
[Br:1][C:2]1[C:3]([F:10])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[BH4-].[Na+]>CO>[Br:1][C:2]1[C:3]([F:10])=[C:4]([CH2:5][OH:6])[CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 220193613-Bromo-2-fluorobenzaldehyde

Produkt 1

HCID 269856463-Bromo-2-fluorobenzyl AlcoholAusbeute 77,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2.00 g of 3-bromo-2-fluorobenzaldehyde are dissolved in 98 ml of methanol; 560 mg of sodium borohydride are added portionwise thereto. The mixture is stirred at ambient temperature for 2 hours and then the solvent is evaporated under reduced pressure. The residue is taken up between water and ethyl acetate and the organic phase is separated, dried and concentrated under reduced pressure. The residue is purified by chromatography on silica gel, elution being carried out with a dichloromethane/methanol mixture. 1.56 g of compound are obtained.

Aufarbeitung

  1. customthe solvent is evaporated under reduced pressure
  2. customthe organic phase is separated
  3. customdried
  4. concentrationconcentrated under reduced pressure
  5. customThe residue is purified by chromatography on silica gel, elution

Quellen und Nachweise

ORD-Eintrag
ord-353e33ce6a734bccb2cc1491d02fb782
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148370B2

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