Ethylamine → HCID 86661276, Verbindung

HRID 1685007Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1685007
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]I)[N:14]=1)=[O:8].[CH2:21]([NH2:23])[CH3:22]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][NH:23][CH2:21][CH3:22])[N:14]=1)=[O:8]

Komponenten

4

Edukt 2

HCID 6341EthylamineHCID 58055059HCID 58055059, Verbindung2×

Produkt 1

HCID 86661276HCID 86661276, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The 1-(3,4-dichloro-benzyl)-3-(4-iodomethyl-thiazol-2-yl)-urea (Intermediate 6, 0.3 mmol) was taken up in a 2.0 M solution of ethylamine in tetrahydrofuran (5 ml). Reaction was stirred at room temperature for 1 hour. The volatiles were removed in vacuo and the crude title compound was taken on as is, ˜75% pure.

Aufarbeitung

  1. customReaction
  2. customThe volatiles were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ffb93c545aa84d1abd32b0be5882851d
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148380B2

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