Morpholine → 6-(Morpholin-4-yl)pyridin-2-amine
Reaktionsgleichung
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[O:12]1[CH2:13][CH2:14][N:9]([C:4]2[N:3]=[C:2]([NH2:1])[CH:7]=[CH:6][CH:5]=2)[CH2:10][CH2:11]1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 225 °C
Versuchsvorschrift
A mixture of 2-amino-6-chloropyridine in 100 mL of morpholine was heated at 225° C. for 60 mins. The mixture was cooled and precipitate filtered off, the filtrate was concentrated to give the 17 gram product as a brown oil.
Aufarbeitung
- temperatureThe mixture was cooled
- filtrationprecipitate filtered off
- concentrationthe filtrate was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-5420d8f6d19e4bcf92b4bfd6b98332b2
- Quelldatensatz
- uspto-grants-2012_04
- Patentnummer
- US08148367B2
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