Water → 3-amino-5,5-dimethyl-8-nitro-3,4-dihydro-1H-1-benzazepin-2-one

HRID 1687635Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1687635
[N:1]([CH:4]1[CH2:10][C:9]([CH3:12])([CH3:11])[C:8]2[CH:13]=[CH:14][C:15]([N+:17]([O-:19])=[O:18])=[CH:16][C:7]=2[NH:6][C:5]1=[O:20])=[N+]=[N-].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1COCC1.O>>[NH2:1][CH:4]1[CH2:10][C:9]([CH3:12])([CH3:11])[C:8]2[CH:13]=[CH:14][C:15]([N+:17]([O-:19])=[O:18])=[CH:16][C:7]=2[NH:6][C:5]1=[O:20]

Komponenten

5

Edukt 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 866339913-Azido-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one

Produkt 1

HCID 672640283-amino-5,5-dimethyl-8-nitro-3,4-dihydro-1H-1-benzazepin-2-one

Versuchsvorschrift

3-Azido-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one (3.10 g, 10.3 mmol), Triphenylphosphine Resin (12 g, 11.55 mmol), THF (120 mL, 1400 mmol) and Water (0.9 mL, 50 mmol) were combined and stirred at rt for 16 h. The reaction mixture was filtered. Product isolated as a beige solid. (HPLC purity >98%)

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customProduct isolated as a beige solid

Quellen und Nachweise

ORD-Eintrag
ord-8fc24e76ef6f4f5280ec1040d7145a45
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148391B2

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