Water → HCID 22693286, Verbindung

HRID 1689839Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1689839
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.C(N(CC)CC)C.[NH:20]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.O>O1CCCC1>[Cl:1][C:2]1[N:11]=[C:10]([N:20]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8119AzepaneHCID 8471TriethylamineHCID 2528862,4-Dichloroquinazoline

Produkt 1

HCID 22693286HCID 22693286, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2,4-dichloroquinazoline (1.0 g) in tetrahydrofuran (10 mL) were added triethylamine (2.1 mL) and perhydroazepine (0.745 mL) with ice cooling and the mixture was stirred for 1 hour at room temperature. To the reaction mixture was added water (20 mL) and the resulting mixture was concentrated. The residue was extracted with methylene chloride three times. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and concentrated. The residue was washed with hexane-diethyl ether (10:1) to give the title compound (991 mg) having the following physical data.

Aufarbeitung

  1. concentrationthe resulting mixture was concentrated
  2. extractionThe residue was extracted with methylene chloride three times
  3. washThe organic layer was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated
  6. washThe residue was washed with hexane-diethyl ether (10:1)

Quellen und Nachweise

ORD-Eintrag
ord-1b21b2602ad049bcad7db8da1035abb4
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08153625B2

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