1-Fluoro-4-methoxy-5-methyl-2-nitrobenzene → 2-Fluoro-5-methoxy-4-methylaniline

HRID 1691814Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1691814
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[N+:11]([O-])=O.[H][H]>CO.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[NH2:11]

Komponenten

5

Edukt 2

HCID 598501391-Fluoro-4-methoxy-5-methyl-2-nitrobenzeneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 593777852-Fluoro-5-methoxy-4-methylanilineAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1-Fluoro-4-methoxy-5-methyl-2-nitro-benzene (1.18 g, 6.4 mmol) was dissolved in 40 ml of methanol at room temperature. 10% Palladium on Carbon (200 mg) was added and the mixture was stirred under a balloon of hydrogen overnight. The mixture was filtered through celite. The filtrate was concentrated in vacuo to give 2-fluoro-5-methoxy-4-methyl-phenylamine (990 mg, quantitative) as a solid.

Aufarbeitung

  1. filtrationThe mixture was filtered through celite
  2. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-064546fbd954456e83c9eb21053b5c0c
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08153809B2

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