Ammonia → HCID 59303060, Verbindung

HRID 1692144Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1692144
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[C:6]([C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)[CH:5]=1.[NH3:33]>O>[C:20]([C:17]1[CH:16]=[CH:15][C:14]([S:11]([NH:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([NH2:33])=[O:2])=[CH:5][C:6]=2[C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)(=[O:13])=[O:12])=[CH:19][CH:18]=1)([CH3:22])([CH3:23])[CH3:21]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 59302970HCID 59302970, Verbindung

Produkt 1

HCID 59303060HCID 59303060, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A 10 mL scintillation vial was charged with 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzoic acid methyl ester (20 mg, 0.044 mmol) and 30% NH3 in H2O (1.5 mL). The reaction was heated to 60° C. and stirred overnight. The following day, the volatiles were removed in vacuo to about 200 μL at which point the solution was purified by preparative TLC to afford 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzamide as a colorless oil: MS (ES) M+H expected 442.2, found 442.4.

Aufarbeitung

  1. customThe following day, the volatiles were removed in vacuo to about 200 μL at which point the solution
  2. customwas purified by preparative TLC

Quellen und Nachweise

ORD-Eintrag
ord-d631e684fc61427cbdd10e9e97dedefb
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08153818B2

Notizen zur Reaktion

Wird geladen…