Isoamyl Nitrite → 2-Chloro-4-(ethylthio)-1-iodo-benzene

HRID 1694707

Reaktionsgleichung

Reaktionsgleichung von HRID 1694707
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[I:9])N.C(ON=O)CC(C)C.[CH2:18]([S:20]SCC)[CH3:19]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([S:20][CH2:18][CH3:19])[CH:6]=[CH:7][C:8]=1[I:9]

Komponenten

5

Edukt 3

HCID 8053Isoamyl NitriteHCID 8077Diethyl disulfideHCID 2829263-Chloro-4-iodoaniline

Produkt 1

HCID 672801852-Chloro-4-(ethylthio)-1-iodo-benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 3-chloro-4-iodo-aniline (5.6 g), isoamylnitrite (8.8 ml) and ethyldisulphide (13.4 ml) in acetonitrile (100 ml) was heated at 60° C. for 24 h. The solvent was removed under reduced pressure and the residue purified by chromatography on silica eluting with 1% ethylacetate/isohexane. Yield 4.02 g

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customthe residue purified by chromatography on silica eluting with 1% ethylacetate/isohexane

Quellen und Nachweise

ORD-Eintrag
ord-7c48071fe59d41d998676c0323da739d
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08158820B2

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