Hydrochloric Acid → 1-Methylpiperidine-2-carboxylic acid

HRID 1695107

Reaktionsgleichung

Reaktionsgleichung von HRID 1695107
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[CH3:12])=[O:5])C.[OH-].[Na+].Cl>CO.O>[CH3:12][N:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH:6]1[C:4]([OH:5])=[O:3]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 566742Ethyl 1-methylpiperidine-2-carboxylate

Produkt 1

HCID 4159391-Methylpiperidine-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

N-Methyl-piperidine-2-carboxylic acid ethyl ester (5.1 g) was dissolved in a mixture of 100 ml methanol and 10 ml water. NaOH (8 g) was added and the reaction mixture was stirred at room temperature overnight. The solution was then neutralized with hydrochloric acid, evaporated to dryness, and evaporated four times with toluene. The resulting powdery residue was used directly in the next step.

Aufarbeitung

  1. customevaporated to dryness
  2. customevaporated four times with toluene

Quellen und Nachweise

ORD-Eintrag
ord-9f4e30bfc478409492ed3c628979e11d
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163698B2

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