Lithium Hydroxide → HCID 11854276, Verbindung

HRID 1695553Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1695553
COC(=O)C(C1C=CC(Cl)=CC=1)N.C[O:15][C:16](=[O:50])[CH:17]([C:43]1[CH:48]=[CH:47][C:46]([Cl:49])=[CH:45][CH:44]=1)[N:18]1[CH:27]([C:28]2[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=2)[CH:26]([C:35](=[O:41])[NH:36][CH2:37][CH2:38][O:39][CH3:40])[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19]1=[O:42].[OH-].[Li+]>O1CCCC1>[Cl:49][C:46]1[CH:47]=[CH:48][C:43]([CH:17]([N:18]2[CH:27]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=3)[CH:26]([C:35](=[O:41])[NH:36][CH2:37][CH2:38][O:39][CH3:40])[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:19]2=[O:42])[C:16]([OH:50])=[O:15])=[CH:44][CH:45]=1

Komponenten

5

Edukt 3

HCID 3939Lithium HydroxideHCID 2763700Methyl 2-amino-2-(4-chlorophenyl)acetateHCID 67276514HCID 67276514, Verbindung

Produkt 1

HCID 11854276HCID 11854276, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Using 4-chlorophenyl-2-amino-acetic acid methyl ester as a primary amine, (4-Chloro-phenyl)-[3-(4-chloro-phenyl)-4-(2-methoxy-ethylcarbamoyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid methyl ester was prepared according to the general procedure of example 1 and 3. The final acid (4-Chloro-phenyl)-[3-(4-chloro-phenyl)-4-(2-methoxy-ethylcarbamoyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid was prepared by treatment with lithium hydroxide in tetrahydrofuran. Molecular Weight=527.4087, calculated from Molecular Formula=C27H24Cl2N2O5. ([M+H]+) observed 526.9.

Aufarbeitung

  1. customwas prepared

Quellen und Nachweise

ORD-Eintrag
ord-01ac122a13e94f96980d7288d6abb1f6
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163744B2

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