Methanesulfonyl chloride → HCID 178488352, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[O:14][CH2:15][C:16]3[CH:22]=[C:21]([NH2:23])[CH:20]=[CH:19][C:17]=3[N:18]=1)[CH2:9][CH2:8]2.[CH3:24][S:25](Cl)(=[O:27])=[O:26]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[O:14][CH2:15][C:16]3[CH:22]=[C:21]([NH:23][S:25]([CH3:24])(=[O:27])=[O:26])[CH:20]=[CH:19][C:17]=3[N:18]=1)[CH2:9][CH2:8]2Komponenten
3
Versuchsvorschrift
Prepared from rac-N2-(7-methoxy-indan-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 10) (155 mg, 0.50 mmol, HPLC 0.776 min) and methanesulfonyl chloride (43 ul, 0.55 mmol) according to the procedure described for Example 27. Obtained the title compound as a light brown solid (84 mg, 43%, HPLC 1.178 min), MS (ISP) m/e=388.3 [(M+H)+].
Quellen und Nachweise
- ORD-Eintrag
- ord-64e5cb658f594e02808dfb6188100db8
- Quelldatensatz
- uspto-grants-2012_04