Sodium Carbonate → N-{6-[5-{[(2,4-Difluorophenyl)sulfonyl]amino}-6-(methyloxy)-3-pyridinyl]-1-[(4-methylphenyl)sulfonyl]-1H-indazol-4-yl}-2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-thiazole-4-carboxamide

Reaktionsgleichung

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[C:14]([O:28][CH3:29])=[N:15][CH:16]=[C:17](B2OC(C)(C)C(C)(C)O2)[CH:18]=1)(=[O:11])=[O:10].Br[C:31]1[CH:39]=[C:38]2[C:34]([CH:35]=[N:36][N:37]2[S:40]([C:43]2[CH:48]=[CH:47][C:46]([CH3:49])=[CH:45][CH:44]=2)(=[O:42])=[O:41])=[C:33]([NH:50][C:51]([C:53]2[N:54]=[C:55]([CH2:58][N:59]3[CH2:64][C@H:63]([CH3:65])[O:62][C@H:61]([CH3:66])[CH2:60]3)[S:56][CH:57]=2)=[O:52])[CH:32]=1.C(=O)([O-])[O-].[Na+].[Na+].O1CCOCC1>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[CH:18]=[C:17]([C:31]2[CH:39]=[C:38]3[C:34]([CH:35]=[N:36][N:37]3[S:40]([C:43]3[CH:48]=[CH:47][C:46]([CH3:49])=[CH:45][CH:44]=3)(=[O:42])=[O:41])=[C:33]([NH:50][C:51]([C:53]3[N:54]=[C:55]([CH2:58][N:59]4[CH2:64][C@H:63]([CH3:65])[O:62][C@H:61]([CH3:66])[CH2:60]4)[S:56][CH:57]=3)=[O:52])[CH:32]=2)[CH:16]=[N:15][C:14]=1[O:28][CH3:29])(=[O:10])=[O:11]