1-Chloro-1-(4-methoxyphenyl)-1-trifluoromethylethane → 1-Methoxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)benzene

Temperatur

95 °C

A solution of 1-(2-chloro-1,1,1-trifluoropropan-2-yl)-4-methoxybenzene (18.0 g, 75 mmol) in 400 ml of hexanes was treated with trimethylaluminum (151 ml, 302 mmol) (2.0 M in heptane) at rt and the resulting mixture was heated at 95° C. overnight. The reaction mixture was cooled in an ice-water bath, conc. HCl was added to the reaction mixture dropwise. Fumes were generated. After about 10 ml of conc. HCl was added, more rapid addition of acid was possible due to the near complete quenching of the unreacted AlMe3. After addition of 100 ml of conc. HCl, 250 ml of H2O was added and the mixture was stirred vigorously for 1 h. The layers were separated. The org layer was dried (Na2SO4) and concentrated to give the title compound as an oil, which solidified upon drying on the vac line.

1. temperatureThe reaction mixture was cooled in an ice-water bath
2. additionmore rapid addition of acid
3. customcomplete quenching of the unreacted AlMe3
4. additionAfter addition of 100 ml of conc. HCl, 250 ml of H2O
5. additionwas added
6. customThe layers were separated
7. dry with materialThe org layer was dried (Na2SO4)
8. concentrationconcentrated

ORD-Eintrag

ord-73539ae066094bd58ac03e111284f719

Quelldatensatz

uspto-grants-2012_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08163909B2