Triethylamine → HCID 178513225, Verbindung

HRID 1697268Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1697268
Cl.[NH2:2][OH:3].C(N(CC)CC)C.[Br:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([C:22]#[N:23])[CH:16]=[CH:15]2>C(O)C>[Br:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([C:22]([NH:2][OH:3])=[NH:23])[CH:16]=[CH:15]2

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 146621156-Bromonaphthalene-2-carbonitrile

Produkt 1

HCID 178513225HCID 178513225, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2.48 g hydroxylamine-hydrochloride and 5.68 ml triethylamine are added to 4.10 g of 6-bromo-2-cyano-naphthalene in 100 ml of ethanol and the reaction mixture is refluxed for four hours. After cooling to ambient temperature the solvent is distilled off in vacuo using the rotary evaporator and the flask residue is divided between water and ethyl acetate. The aqueous phase is extracted with ethyl acetate and the combined organic phases are dried on magnesium sulphate and evaporated down.

Aufarbeitung

  1. temperaturethe reaction mixture is refluxed for four hours
  2. distillationis distilled off in vacuo
  3. customthe rotary evaporator
  4. extractionThe aqueous phase is extracted with ethyl acetate
  5. customthe combined organic phases are dried on magnesium sulphate
  6. customevaporated down

Quellen und Nachweise

ORD-Eintrag
ord-de8976d12e9940d2bc603ab462d1e8e3
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163911B2

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