Acetic Acid → HCID 46947220, Verbindung
Reaktionsgleichung
Cl.[C:2]([C:4]1([NH:7][C:8]([C@@H:10]2[CH2:14][C@@H:13]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])(=[O:17])=[O:16])[CH2:12][NH:11]2)=[O:9])[CH2:6][CH2:5]1)#[N:3].[C:25](O)(=[O:27])[CH3:26]>>[C:2]([C:4]1([NH:7][C:8]([C@@H:10]2[CH2:14][C@@H:13]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])(=[O:17])=[O:16])[CH2:12][N:11]2[C:25](=[O:27])[CH3:26])=[O:9])[CH2:6][CH2:5]1)#[N:3]Komponenten
3
Versuchsvorschrift
(2S,4R)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide hydrochloride from experiment K4 was coupled with acetic acid in analogy to experiment A1 to give (2S,4R)-1-acetyl-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide as a colorless solid. MS: 496.0 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-82c0e250113b4404b03bf7013802069d
- Quelldatensatz
- uspto-grants-2012_04
- Patentnummer
- US08163793B2