Lithium Hydroxide → (2S,4R)-1-(2-Benzyl-5-methyl-2H-pyrazol-3-yl)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid

HRID 1697654Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1697654
C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])(=[O:12])=[O:11])[CH2:7][N:6]1[C:20]1[N:21]([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:22]=[C:23]([CH3:25])[CH:24]=1)=[O:4].[OH-].[Li+]>>[CH2:26]([N:21]1[C:20]([N:6]2[CH2:7][C@H:8]([S:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])(=[O:11])=[O:12])[CH2:9][C@H:5]2[C:3]([OH:4])=[O:2])=[CH:24][C:23]([CH3:25])=[N:22]1)[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Komponenten

3

Edukt 2

HCID 3939Lithium HydroxideHCID 66770380(2S,4R)-1-(2-Benzyl-5-methyl-2H-pyrazol-3-yl)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester

Produkt 1

HCID 66770922(2S,4R)-1-(2-Benzyl-5-methyl-2H-pyrazol-3-yl)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid

Versuchsvorschrift

In analogy to the procedure described in example 253e, (2S,4R)-1-(2-benzyl-5-methyl-2H-pyrazol-3-yl)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as yellow oil which was used in the next step without further purification. MS (ESI): m/z=460.3 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-fd9d6de5bf4d4977b3ac4df5c69f060d
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163793B2

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