Lithium Hydroxide → HCID 178525800, Verbindung

HRID 1697682Notizen

Reaktionsgleichung

C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23]1[NH:24][N:25]=[C:26]([CH:28]2[CH2:30][CH2:29]2)[CH:27]=1)=[O:4].[OH-].[Li+]>>[CH:28]1([C:26]2[CH:27]=[C:23]([N:6]3[CH2:7][C@H:8]([S:10]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=4[C:19]([F:22])([F:20])[F:21])(=[O:12])=[O:11])[CH2:9][C@H:5]3[C:3]([OH:4])=[O:2])[NH:24][N:25]=2)[CH2:29][CH2:30]1

Komponenten

Edukt 2

HCID 3939Lithium Hydroxide

HCID 178501348HCID 178501348, Verbindung

Produkt 1

HCID 178525800HCID 178525800, Verbindung

Versuchsvorschrift

In analogy to the procedure described in example 253e, (2S,4R)-1-(5-cyclopropyl-2H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as brown solid which was used in the next step without further purification.

Quellen und Nachweise

ORD-Eintrag: ord-5f5dc102c37b4ac4bbfa2905a09d9532
Quelldatensatz: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08163793B2

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