Cyclopropylamine → N-(3-methoxy-5-(3-methoxypropoxy)benzyl)cyclopropanamine
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][O:15][CH3:16])[CH:10]=1)[CH:6]=O.[CH:17]1([NH2:20])[CH2:19][CH2:18]1>CC#N>[CH:17]1([NH:20][CH2:6][C:5]2[CH:8]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][O:15][CH3:16])[CH:10]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:19][CH2:18]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The title compound is synthesized by reductive amination of 3-Methoxy-5-(3-methoxy-propoxy)-benzaldehyde (2.50 g, 11.1 mmol) with cyclopropylamine (855 mg, 15.0 mmol) analogously to the preparation of Example 152. Yellow oil; MS: 266 [M+H]+; tR (HPLC, CombiScreen ODS-AM 50×4.6 mm; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 5 min then 100% CH3CN+0.1% TFA for 2 min, flow 2.0 ml/min): 2.48 min.