9-Nitro-2,3-dihydro-4,1-benzoxazepin-5(1H)-one → 9-Amino-2,3-dihydro-4,1-benzoxazepin-5(1H)-one

HRID 1698539Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1698539
[N+:1]([C:4]1[C:14]2[NH:13][CH2:12][CH2:11][O:10][C:9](=[O:15])[C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[C:14]2[NH:13][CH2:12][CH2:11][O:10][C:9](=[O:15])[C:8]=2[CH:7]=[CH:6][CH:5]=1

Komponenten

4

Edukt 1

HCID 672730729-Nitro-2,3-dihydro-4,1-benzoxazepin-5(1H)-one

Produkt 1

HCID 672729029-Amino-2,3-dihydro-4,1-benzoxazepin-5(1H)-oneAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 500 mg (2.42 mmol) of 9-nitro-2,3-dihydro-4,1-benzoxazepin-5(1H)-one in 500 mL of methanol was inerted with nitrogen. To this solution was added 100 mg of 10% palladium on carbon (50% wet) and the reaction was purged with hydrogen and stirred under balloon pressure hydrogen for 6 h. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to give 430 mg (99%) of the title compound.

Aufarbeitung

  1. customthe reaction was purged with hydrogen
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-19ace845a53e44c3a014e99d98a360ee
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163935B2

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