Hydrogen Bromide → 1-(Bromomethyl)-4-(2-methylpropyl)benzene

HRID 1699007Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1699007
[BrH:1].[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12]O)=[CH:8][CH:7]=1)[CH:3]([CH3:5])[CH3:4]>CCOCC>[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][Br:1])=[CH:8][CH:7]=1)[CH:3]([CH3:5])[CH3:4]

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 14620446[4-(2-Methylpropyl)phenyl]methanol

Produkt 1

HCID 146204471-(Bromomethyl)-4-(2-methylpropyl)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

HBr gas was bubbled through a solution of (4-isobutyl-phenyl)-methanol (5 g, 28 mmol) in Et2O (50 mL) for 10-15 minutes. The reaction was stirred for 1 h and was poured onto ice (100 g). Et2O was added and the organic solution was washed with brine (2×). The organic solution was dried (MgSO4), filtered, and concentrated to provide the title compound (6 g). 1H NMR (400 MHz, CDCl3) δ7.28 (d, 2H), 7.10 (d, 2H), 4.49 (s, 2H), 2.45 (d, 2H), 1.84 (m, 1H), 0.89 (d, 6H).

Aufarbeitung

  1. additionwas poured onto ice (100 g)
  2. washthe organic solution was washed with brine (2×)
  3. dry with materialThe organic solution was dried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-64d1464bc70f4693a96514d804ef5629
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06344485B1

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