Hydrazine hydrate (1:1) → 3-Methyl-6-(2-chlorophenyl)-4,5,6,7-tetrahydroindazol-4-one

HRID 1700450Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700450
O[C:2](=[C:4]1[C:9](=O)[CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[CH2:6][C:5]1=[O:18])[CH3:3].O.[NH2:20][NH2:21]>C(O)C>[Cl:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH:7]1[CH2:8][C:9]2[NH:21][N:20]=[C:2]([CH3:3])[C:4]=2[C:5](=[O:18])[CH2:6]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 178467253HCID 178467253, Verbindung

Produkt 1

HCID 1784341903-Methyl-6-(2-chlorophenyl)-4,5,6,7-tetrahydroindazol-4-oneAusbeute 85,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-(1-hydroxyethylidene)-5-(2-chlorophenyl)cyclohexane-1,3-dione (0.31 g) and hydrazine hydrate (0.065 g) in ethanol (10 ml) was refluxed for 30 minutes. Under reduced pressure, the solvent was evaporated, and the residue was recrystallized from ethyl acetate-hexane to give colorless crystals of 6-(2-chlorophenyl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (0.26 g).

Aufarbeitung

  1. customUnder reduced pressure, the solvent was evaporated
  2. customthe residue was recrystallized from ethyl acetate-hexane

Quellen und Nachweise

ORD-Eintrag
ord-4714fccebfb64bd08104b79029209840
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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