Hydrochloric Acid → HCID 178421664, Verbindung

HRID 1700741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700741
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:16][C:15]2[C:11](=[C:12]([CH3:26])[N:13]([CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:14]=2)[C:10](=O)[CH2:9]1.[C:28]([NH:31][NH2:32])([NH2:30])=[NH:29].Cl.Cl.O>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:16][C:15]2[C:11](=[C:12]([CH3:26])[N:13]([CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:14]=2)[C:10](=[N:32][NH:31][C:28]([NH2:30])=[NH:29])[CH2:9]1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 183174356-(2-Chlorophenyl)-3-methyl-2-(3-phenylpropyl)-4,5,6,7-tetrahydroindazol-4-oneHCID 178418668HCID 178418668, Verbindung

Produkt 1

HCID 178421664HCID 178421664, VerbindungAusbeute 154,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 6-(2-chlorophenyl)-3-methyl-2-(3-phenylpropyl)-4,5,6,7-tetrahydroindazol-4-one (0.25 g), aminoguanidine hydrochloride (0.11 g), concentrated hydrochloric acid (0.16 ml), water (0.16 ml) and ethanol (15 ml) was refluxed for 8 hours. Under reduced pressure, the solvent was evaporated, and the resulting crystals were recrystallized from ethanol-water to give 6-(2-chlorophenyl)-4-guanidinoimino-3-methyl-2-(3-phenylpropyl)-4,5,6,7-tetrahydroindazole hydrochloride (Compound 154) (0.24 g) as colorless crystals.

Aufarbeitung

  1. temperaturewas refluxed for 8 hours
  2. customUnder reduced pressure, the solvent was evaporated
  3. customthe resulting crystals were recrystallized from ethanol-water

Quellen und Nachweise

ORD-Eintrag
ord-61db1abdcf724895876e81d3d8bc011c
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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