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Ethylene Glycol → 20,20-Ethylenedioxy-3beta-hydroxy-5alpha-pregn-16-en-11-one

HRID 1701456
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1701456
[OH:1][C@H:2]1[CH2:21][CH2:20][C@@:19]2([CH3:22])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:18]2[C:17](=[O:23])[CH2:16][C@@:15]2([CH3:24])[C@H:8]3[CH2:9][CH:10]=[C:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1.[CH2:25](O)[CH2:26][OH:27].C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1C=CC=CC=1.C(OCC)(=O)C>[CH2:25]1[CH2:26][O:27][C:12]([C:11]2[C@:15]3([CH3:24])[C@H:8]([C@H:7]4[C@H:18]([C:17](=[O:23])[CH2:16]3)[C@:19]3([CH3:22])[C@H:4]([CH2:3][C@@H:2]([OH:1])[CH2:21][CH2:20]3)[CH2:5][CH2:6]4)[CH2:9][CH:10]=2)([CH3:13])[O:14]1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

7

Edukt 4

HCID 174Ethylene GlycolHCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 705834293beta-Hydroxy-5alpha-pregn-16-ene-11,20-dione

Produkt 1

HCID 7058342320,20-Ethylenedioxy-3beta-hydroxy-5alpha-pregn-16-en-11-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 241
Benzene
Lösungsmittel
HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3β-Hydroxy-5α-pregn-16-ene-11,20-dione (3 g) was refluxed with ethylene glycol (8 ml) in benzene (150 ml) containing p-toluenesulphonic acid (150 mg) under a Dean Stark water separator for 20 hours. The mixture was diluted with ethyl acetate, washed with sodium hydrogen carbonate solution, and brine, and dried (sodium sulphate). Evaporation gave 20,20-ethylenedioxy-3β-hydroxy-5α-pregn-16-en-11-one (3.42 g) as a white foam. This foam was dissolved in ethanol (170 ml) and sodium borohydride (2.1 g) in water (21 ml) was added with stirring under reflux. After 1.25 hours, most of the ethanol was evaporated and the residue was partitioned between ethyl acetate and water. The ethyl acetate extract was washed, and evaporated to small volume. This solution was filtered through silica gel (100 g) in ethyl acetate. Evaporation of the eluate gave 20,20-ethylenedioxy-5α-pregn-16-ene-3β,11β-diol (2.45 g) as a white foam which was heated on a steam bath for 1 hour in acetic acid (24 ml) and water (25 ml). The mixture was concentrated and diluted with water. The solid was collected by filtration, washed, and dried. Recrystallisation from ethyl acetate-acetone gave title compound (97 mg), m.p. 214°-218°, [α]D +82.1°.

Aufarbeitung

  1. washwashed with sodium hydrogen carbonate solution, and brine
  2. dry with materialdried (sodium sulphate)
  3. customEvaporation

Quellen und Nachweise

ORD-Eintrag
ord-39eba80613ba45c6947374a94272e03c
Quelldatensatz
uspto-grants-1980_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04192871

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