Boron trifluoride etherate → 2-[4-(4-Chlorophenyl)phenyl]-5-ethyl-5-phenyl-1,3-dioxolan-4-one

To a stirred solution of 4-(4-chlorophenyl)benzaldehyde (2.16 g.) and 2-hydroxy-2-phenylbutyric acid (1.8 g.) in anhydrous diethyl ether (50 ml.) was added boron trifluoride etherate (2.2 g.). After stirring at room temperature for 12 hours, the solution was washed with 10% w/v sodium acetate solution (2×20 ml.) and then with water (2×20 ml.) and dried (Na2SO4). The solution was filtered and evaporated to give an oil which on crystallisation from methanol gave 2-[4-(4-chlorophenyl)phenyl]-5-ethyl-5-phenyl-1,3-dioxolan-4-one (1.7 g.) m.p. 80°-83° C.

1. washthe solution was washed with 10% w/v sodium acetate solution (2×20 ml.)
2. dry with materialwith water (2×20 ml.) and dried (Na2SO4)
3. filtrationThe solution was filtered
4. customevaporated
5. customto give an oil which
6. customon crystallisation from methanol

ORD-Eintrag

ord-1041ae49bc89418596993a2520478c20

Quelldatensatz

uspto-grants-1982_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04348322