Ammonium Acetate → N-(4-Hydroxyphenyl)glycine

HRID 1703061

Reaktionsgleichung

Reaktionsgleichung von HRID 1703061
O.[OH:2][C:3]1[CH:13]=[CH:12][C:6](C(O)C([O-])=O)=[CH:5][CH:4]=1.[Na+].[C:15]([O-:18])(=[O:17])[CH3:16].[NH4+:19]>O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([NH:19][CH2:16][C:15]([OH:18])=[O:17])=[CH:12][CH:13]=1

Komponenten

4

Edukt 2

HCID 517165Ammonium AcetateHCID 236981332-Hydroxy-2-(4-hydroxyphenyl)acetic acid, sodium salt hydrate

Produkt 1

HCID 67149N-(4-Hydroxyphenyl)glycineAusbeute 67 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
125 °C

Versuchsvorschrift

A mixture of sodium p-hydroxymandelate monohydrate (1.04 g.), ammonium acetate (2.0 g.) and water (0.5 ml.) is stirred and heated under reflux (internal temperature 125° C.) for 2.5 hours. Water (3 ml.) is added to the thick slurry thus obtained, the mixture is cooled and filtered and the solid residue is washed twice with water and then with acetone. There is thus obtained p-hydroxyphenylglycine (0.56 g., 66% yield).

Aufarbeitung

  1. temperatureheated
  2. customthus obtained
  3. temperaturethe mixture is cooled
  4. filtrationfiltered
  5. washthe solid residue is washed twice with water

Quellen und Nachweise

ORD-Eintrag
ord-5199c7298b8e4d23b317a13a977cf9e7
Quelldatensatz
uspto-grants-1982_09
Patentnummer
US04350826

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