Triethylamine → HCID 13079701, Verbindung

HRID 1703101Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1703101
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][OH:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>ClCCl>[CH3:26][S:27]([O:18][CH2:17][CH2:16][CH2:15][C:12]1[CH:11]=[CH:10][C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:14][CH:13]=1)(=[O:29])=[O:28]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 27640763-(4-(Benzyloxy)phenyl)propan-1-ol

Produkt 1

HCID 13079701HCID 13079701, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

To a solution of 11.0 g. of 3-[p-(benzyloxy)phenyl]propanol and 10.4 ml. of triethylamine in 175 ml. of dichloromethane chilled to -10° C. is added dropwise, over 10 minutes, a solution of 3.89 ml. of methanesulfonyl chloride in 10 ml. of dichloromethane. The solution is stirred at -10° C. for 30 minutes, washed with 150 ml. of cold water, 75 ml. of cold 10% HCl, 75 ml. of cold saturated sodium bicarbonate, 75 ml. of cold saturated sodium chloride solution and dried over magnesium sulfate. The solvent is removed in vacuo to give off-white crystals, m.p. 65°-69° C.

Aufarbeitung

  1. additionis added dropwise, over 10 minutes
  2. washwashed with 150 ml
  3. dry with materialof cold saturated sodium chloride solution and dried over magnesium sulfate
  4. customThe solvent is removed in vacuo
  5. customto give off-white crystals, m.p. 65°-69° C.

Quellen und Nachweise

ORD-Eintrag
ord-6ae58c997ae64fbca6bed664343072b0
Quelldatensatz
uspto-grants-1982_09
Patentnummer
US04350822

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