Water → 7-Bromo-5-methyl-3-phenylbenzofuran

HRID 1703558

Reaktionsgleichung

Reaktionsgleichung von HRID 1703558
[Br:1][C:2]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:3]=1[O:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O.O>C(Cl)(Cl)Cl>[Br:1][C:2]1[C:3]2[O:4][CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]=2[CH:15]=[C:16]([CH3:18])[CH:17]=1

Komponenten

4

Edukt 2

HCID 962WaterHCID 40772362-(2-Bromo-4-methylphenoxy)acetophenone

Produkt 1

HCID 213199287-Bromo-5-methyl-3-phenylbenzofuran

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A mixture of 700 g. of polyphosphoric acid and 100 g. of α-(2-bromo-4-methylphenoxy)acetophenone is heated at 80°-90° C. for two hours, then poured into two liters of water with stirring. Chloroform (1 liter) is added, and the phases are separated. The organic layer is washed with water, dried, then evaporated to provide 7-bromo-5-methyl-3-phenylbenzofuran as a brown oil.

Aufarbeitung

  1. additionA mixture of 700 g
  2. customthe phases are separated
  3. washThe organic layer is washed with water
  4. customdried
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-cae0c244fee247488e81e68e0fc2c5a9
Quelldatensatz
uspto-grants-1978_11
Patentnummer
US04124704

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