Potassium Carbonate → 3-(Benzyloxy)piperidine

HRID 1703699Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1703699
C([N:4]1[CH2:9][CH2:8][CH2:7][CH:6]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:5]1)(=O)C.[OH-].[Na+].C(=O)([O-])[O-].[K+].[K+]>O>[CH2:11]([O:10][CH:6]1[CH2:7][CH2:8][CH2:9][NH:4][CH2:5]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 205061191-Acetyl-3-benzyloxypiperidine

Produkt 1

HCID 199606043-(Benzyloxy)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1-Acetyl-3-benzyloxypiperidine (0.043 mole), sodium hydroxide (0.086 mole) and water (30 ml.) are combined and refluxed for 24 hours. The reaction mixture is saturated with potassium carbonate and extracted three times with ether. The ether is removed by evaporation and the yellow oil is distilled at 92°-94° C. (0.3 mm Hg.).

Aufarbeitung

  1. temperaturerefluxed for 24 hours
  2. extractionextracted three times with ether
  3. customThe ether is removed by evaporation
  4. distillationthe yellow oil is distilled at 92°-94° C. (0.3 mm Hg.)

Quellen und Nachweise

ORD-Eintrag
ord-586489c2d83f4e39ac3a196f43ad07df
Quelldatensatz
uspto-grants-1978_11
Patentnummer
US04124590

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