Sodium Hydroxide → HCID 23684697, Verbindung

HRID 1704334Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1704334
[NH2:1][C:2]1[C:7]([C:8](=[O:16])[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([OH:20])=[O:19].[OH-].[Na+:22]>O>[OH2:16].[NH2:1][C:2]1[C:7]([C:8](=[O:16])[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([O-:20])=[O:19].[Na+:22]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 173842Ahr 6293

Produkt 1

HCID 23684697HCID 23684697, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 3.5 g. (0.0125 mole) of 2-amino-3-(p-chlorobenzoyl)phenylacetic acid in a water solution containing 0.5 g. of sodium hydroxide (0.0125 mole) was refluxed 45 minutes, cooled and filtered. The filtrate was concentrated to an oily consistency and poured into a large volume of acetone. A yellow precipitate separated which was collected and identified by nuclear magnetic resonance spectrum as the desired product. The product (2.6 g.) 67%) melted at 265° C. (dec.) after crystallization from ethanol-ethyl ether.

Aufarbeitung

  1. additionA mixture of 3.5 g
  2. temperaturecooled
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated to an oily consistency
  5. additionpoured into a large volume of acetone
  6. customA yellow precipitate separated which
  7. customwas collected
  8. customThe product (2.6 g.) 67%) melted at 265° C. (dec.) after crystallization from ethanol-ethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-f6495d210438435d9b823b961a0f238e
Quelldatensatz
uspto-grants-1978_11
Patentnummer
US04126635

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